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For Healthy Aging!

Working as a powerful Nrf2 Activator, Protandim acts as a ‘master switch’ regulator to over 3000 genes, 500 of which are often referred to as “survival genes”.

What is Nfr2 & HOW Does It Help You
'Biohack' the Aging Code?

Nfr2 is a protein within our cells that modulates hundreds of cells that are involved in:

  • Protecting cells from oxidative stress caused by free radicals and other oxidants
  • Maintaining the balance between immune function and mediators of inflammation
  • Providing cardiovascular protection and responsiveness
  • Protecting cells and organs from age-related loss of function
  • Maintaining cognitive function

Protandim Testimonial
By Teen Idol of the Seventies
Donny Osmond

Protandim®, the Nrf2 Synergizer,
is a Biochemical Approach to Anti-Aging!

Protandim® works differently than any other conventional antioxidant or anti-aging supplement because it signals the body to do what it is already programmed to do: It tells your DNA to not only increase the production of antioxidant enzymes like SOD, Catalese and Glutathione, but to also activate Nrf2, (Nuclear factor-erythroid-2-related factor 2) which turns on defensive and detoxifying enzymes that protect against cellular damage. It up-regulates stress-responsive and cytoprotective enzymes proteins, and survival genes that help fight stress and protect against inflammation and fibrosis. This is important because premature aging and chronic disease states share oxidative stress and inflammation as causative role players!


Synergistic Induction of Heme Oxygenase-1 by the Components of an Antioxidant Supplement Protandim® Free Radical Biology and Medicine (2009)

Abstract: Protandim® is a supplement formulated with the objective of combining multiple phytochemicals at low non-toxic doses to gain synergy for induction of endogenous antioxidant enzymes. All components together produced a strongly synergistic induction of around three to ninefold, greatly exceeding the sum of the parts, and strongly suggesting this may be an effective method for the induction of antioxidant enzymes.

Conclusion: Protandim® produces a 300% increase in the cellular production of glutathione. As a key antioxidant, glutathione plays critical roles in the regenesis of other antioxidants (vitamins C and E), liver detoxification and elimination, and tissue repair. Further, Protandim® was shown to be a Nrf2 Activator. Findings show nuclear translocation of Nrf2 to the Antioxidant Response Element sites of genes on the DNA. Nrf2 then “re-tunes” the associated genes to function optimally.

Free Radical Biology & Medicine: The Official Journal of the Society for Free Radical Biology and Medicine

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